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CPSF6
Anti-CPSF6 Recombinant Antibody Products
- Recombinant Mouse Anti-Human CPSF6 Antibody (MOB-0730MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF, IP
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- AbPlus™ Anti-CPSF6 Magnetic Beads (VS-0724-YC756) (VS-0724-YC756)
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- Target: CPSF6
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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- Anti-CPSF6 Immunohistochemistry Kit (VS-0325-XY529)
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- Species Reactivity: Human, Mouse, Rat
- Target: CPSF6
- Application: IHC
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For Research Use Only. Not For Clinical Use.
CPSF6 (Cleavage And Polyadenylation Specific Factor 6) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 in disease and FGFR1 mutant receptor activation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPSF7.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7 (PubMed:9659921, PubMed:8626397, PubMed:14561889, PubMed:20695905, PubMed:23187700). The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery (PubMed:29276085). Associates with the exon junction complex (EJC) (PubMed:19864460). Associates with the 80S ribosome particle (PubMed:19864460). Interacts (via the RRM domain) with NUDT21/CPSF5; this interaction is direct and enhances binding to RNA (PubMed:14561889, PubMed:15169763, PubMed:19864460, PubMed:29276085, PubMed:21295486). Interacts (via Arg/Ser-rich domain) with FIP1L1 (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085). Interacts (via N-terminus) with NXF1; this interaction is direct (PubMed:19864460). Interacts with SRSF3 (PubMed:15169763). Interacts with SRSF7 (PubMed:15169763). Interacts with SNRNP70 (PubMed:14561889). Interacts with TRA2B/SFRS10 (PubMed:15169763). Interacts with UPF1 (PubMed:19864460). Interacts with UPF3B (PubMed:19864460). Interacts with VIRMA (PubMed:29507755). Interacts (via Arg/Ser-rich domain) with TNPO3; promoting nuclear import of CPSF6 independently of its phosphorylation status (PubMed:30916345). Interacts with YTHDC1 (By similarity). (Microbial infection) Interacts (via C-terminus) with HIV-1 capsid protein p24 (CA).
Molecular function
RNA-binding
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