Anti-CPT2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in rare disease research, providing premium anti-CPT2 recombinant antibodies for your projects. Carnitine Palmitoyltransferase 2 (CPT2), a key mitochondrial enzyme, completes the import process of fatty acids into mitochondria, allowing for fatty acid oxidation and energy production. Creative Biolabs' clinically validated antibodies help diagnose CPT2 deficiency, the most common form of fatty acid oxidation disorder, as well as to study the basic mechanisms of mitochondrial metabolism.

CPT2: The Final Step in Fatty Acid Import

Carnitine Palmitoyltransferase 2 (CPT2) is an enzyme that is bound to the inner mitochondrial membrane. CPT2 operates in tandem with CPT1 and a translocase. CPT1 first converts the fatty acyl-CoA to an acylcarnitine at the outer mitochondrial membrane. The acylcarnitine is then shuttled into the mitochondrial matrix and CPT2 catalyzes the reverse reaction to convert the acylcarnitine back to a fatty acyl-CoA (inside the mitochondrion) with the concomitant release of free carnitine. This process effectively traps the fatty acid inside the mitochondrial matrix, at which point it is "committed" to beta-oxidation. CPT2 deficiency is the most common genetic cause of fatty acid oxidation disorders, where patients have muscle pain, rhabdomyolysis, and in more severe cases heart and liver failure.

Alternative Names

Carnitine Palmitoyltransferase 2; Carnitine Palmitoyltransferase II; EC 2.3.1.21; CPT II; CPT1; Carnitine O-Palmitoyltransferase 2, Mitochondrial; Testicular Secretory Protein Li 13; CPTASE; IIAE4;

Background

CPT2 (Carnitine Palmitoyltransferase 2) is a Protein Coding gene. Diseases associated with CPT2 include Carnitine Palmitoyltransferase Ii Deficiency, Infantile and Carnitine Palmitoyltransferase Ii Deficiency, Myopathic, Stress-Induced. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and carnitine O-palmitoyltransferase activity.

Anti-CPT2 rAb Products

Creative Biolabs' anti-CPT2 recombinant antibodies are highly specific, high-performance reagents rigorously validated for diagnostic use. They are primarily used for Western Blot analysis of patient-derived fibroblast or muscle lysates to confirm absence or reduction of the CPT2 protein. They are also optimized for IHC and immunofluorescence to study its subcellular localization on the inner mitochondrial membrane.

Table 1. Featured anti-CPT2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has embraced the latest technologies to support the development of cutting-edge reagents in the most efficient manner possible. Our anti-CPT2 recombinant antibodies are expressed in optimized systems to produce the best affinity and specificity for this important mitochondrial protein.

Featured Anti-CPT2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CPT2 recombinant antibody production.

Fig.2 Gram-scale anti-CPT2 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to offering the research community flexible, state-of-the-art tools for basic and applied research. Our anti-CPT2 recombinant antibodies are available in multiple modalities optimized for the unique needs of diagnostic labs and researchers developing the next generation of therapeutics to treat metabolic disorders.

Fig.3 Full-length anti-CPT2 recombinant antibody production and modalities.

Help advance the diagnosis and research of fatty acid oxidation disorders with Creative Biolabs' high-quality anti-CPT2 recombinant antibodies. Defined by its superior specificity and rigorous validation, Creative Biolabs' antibody portfolio gives you the confidence to know you are getting the best tools for diagnostic and basic research. We are experts in the field and want to support you and your work. Contact a Creative Biolabs specialist today.