Anti-CRABP2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers oncology and dermatology experts anti-CRABP2 recombinant antibodies. Cellular Retinoic Acid-Binding Protein 2 (CRABP2) is the principal protein delivering retinoic acid (RA) to its nuclear receptors, and is thus a direct activator of vitamin A signaling. Our high-quality antibodies are an invaluable research tool for interrogating its critical functions in skin biology, cancer treatment, and differentiation programs.

CRABP2: A Nuclear Delivery Vehicle for Retinoic Acid

Cellular Retinoic Acid-Binding Protein 2 (CRABP2) is a small cytosolic protein that, similar to its CRABP1 homolog, binds all-trans-retinoic acid (atRA) with high affinity. However, CRABP2 has a unique and opposing function. While CRABP1 facilitates atRA catabolism, CRABP2 is a shuttle. Binding atRA induces a conformational shift in CRABP2, which allows it to relocate to the nucleus. Once in the nucleus, CRABP2 directly binds the retinoic acid receptors (RARs), and then “channels” its atRA ligand into the receptor’s ligand-binding pocket. This greatly accelerates the efficiency of RAR-dependent gene transcription, establishing CRABP2 as a major positive regulator of the retinoid signaling pathway.

Alternative Names

Cr; Crab; Crabp-2; CrabpII; AI893628; cellular retinoic acid-binding protein 2; CRABP-II

Background

CRABP2 (Cellular Retinoic Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with CRABP2 include Embryonal Carcinoma and Basal Cell Carcinoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is CRABP1.

Anti-CRABP2 rAb Products

Creative Biolabs’ anti-CRABP2 recombinant antibodies are engineered to the highest standards of specificity. They are validated to detect the CRABP2 protein with no cross-reactivity to the closely related CRABP1 isoform. Optimized for IHC to study CRABP2 protein expression in skin and tumors, or cellular fractionation studies by Western Blot, our rAbs are guaranteed to deliver clear, unambiguous results for your experiments.

Table 1. Featured anti-CRABP2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs’ recombinant antibody platforms are underpinned by state-of-the-art production technologies that are tailored to the needs of the unique field of cell signaling. Our anti-CRABP2 recombinant antibodies are expressed in systems that are optimized to ensure high-fidelity recognition of the native protein, and thus a highly specific, and active tool for your experiments.

Featured Anti-CRABP2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CRABP2 recombinant antibody production.

Fig.2 Gram-scale anti-CRABP2 recombinant antibody production.

rAb Modalities

Creative Biolabs is driven by its mission to enable scientific discovery. We deliver on this vision by providing customers with flexible antibody solutions. Our anti-CRABP2 recombinant antibodies are available in multiple modalities to empower researchers around the world to study this critical signaling pathway.

Fig.3 Full-length anti-CRABP2 recombinant antibody production and modalities.

Get the very best from Creative Biolabs, and discover the essential roles of CRABP2 in RA-dependent gene activation with our recombinant antibodies. Defined by high isoform specificity and comprehensive validation, our portfolio is an ideal fit for your needs. Partner with us for quality designed to fast-track your research. Get in touch with our team of experts today.