


Anti-CRBN Recombinant Antibody Products

Anti-CRBN Products
- Mouse Anti-CRBN Recombinant Antibody (clone 8C1) (MOB-3265z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
- Anti-CRBN Immunohistochemistry Kit (VS-0525-XY1659)
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- Species Reactivity: Human
- Target: CRBN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Creative Biolabs is a top provider of high-quality reagents and services for life science researchers. Our comprehensive line of anti-CRBN antibody products demonstrates our dedication to quality. These antibodies are meticulously engineered to ensure optimal specificity, sensitivity, and reproducibility, making them invaluable tools for researchers investigating the role of CRBN in various biological processes, particularly in the context of cancer research.
CRBN: A Prospective Therapeutic Target for Cancer
Cereblon (CRBN), a protein involved in the ubiquitin-proteasome system, has emerged as a promising target for cancer therapy. Its unique ability to interact with small molecules and induce the degradation of specific proteins offers a novel approach to treating various cancers. While the field of CRBN-based cancer therapy is still in its early stages, the initial findings suggest that it may offer a valuable addition to the therapeutic armamentarium for patients with cancer. Continued research and development are required to fully realize the promise of this intriguing method.
Alternative Names
Cereblon; MRT2; MRT2A.
Background
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Intracellular
Low cell type specificity
Immune cell enhanced (basophil)
Low cell line specificity
Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts directly with DDB1 (PubMed:25043012, PubMed:25108355). Interacts (in pomalidomide-bound form) with IKZF1 and IKZF3 (PubMed:24328678). Interacts with ILF2 (PubMed:33009960).
Anti-CRBN rAb Products
Creative Biolabs presents a diverse selection of high-quality anti-CRBN antibodies, expertly designed for exceptional performance across various research applications. Our rigorously validated reagents guarantee outstanding specificity, sensitivity, and reproducibility, empowering researchers to delve into the complexities of CRBN biology. With multiple formats and customization options, we equip you with the essential tools to advance your research and make significant discoveries.
Table 1. Featured anti-CRBN recombinant antibody products at Creative Biolabs.
Cat. No. | Product Name | Target Species | Host Species | Applications |
MOB-3265z | Mouse Anti-CRBN Recombinant Antibody (clone 8C1) | Human | Mouse IgG1 | WB, IHC, ELISA |
Creative Quality Control
Creative Biolabs offers an extensive selection of premium anti-CRBN antibodies, each rigorously tested to ensure top performance across various applications. Our commitment to quality ensures that our products adhere to the highest industry standards, delivering reliable and consistent results to support your research endeavors.
Customer Reviews

Mouse Anti-CRBN Recombinant Antibody (clone 8C1) (MOB-3265z)

Mouse Anti-CRBN Recombinant Antibody (clone 8C1) (MOB-3265z)
rAb Production
Creative Biolabs' cutting-edge recombinant antibody platform harnesses the power of genetic engineering to create high-quality anti-CRBN antibodies. This novel technique enables efficient and adjustable manufacturing, assuring a continuous supply of antibodies suited to the unique demands of researchers across disciplines.
Featured Anti-CRBN Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CRBN recombinant antibody production.
Fig.2 Gram-scale anti-CRBN recombinant antibody production.
rAb Modalities
Creative Biolabs delivers a large assortment of high-quality anti-CRBN recombinant antibodies available in a variety of forms to meet your individual research requirements.
Fig.3 Full-length anti-CRBN recombinant antibody production and modalities.
CRBN-Targeted Drug Information-1
Table 2. Public drug targeting CRBN.
Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
Biological Testing |
Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Epigenetic Modifier Modulators |
Drug Conjugates PROTACs (Proteolysis Targeting Chimeras) |
Cancer | China Pharmaceutical University (Originator) |
Biological Testing |
Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Epigenetic Modifier Modulators |
Drug Conjugates PROTACs (Proteolysis Targeting Chimeras) |
Cancer | China Pharmaceutical University (Originator) |
Biological Testing |
Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Epigenetic Modifier Modulators |
Drug Conjugates PROTACs (Proteolysis Targeting Chimeras) |
Cancer | China Pharmaceutical University (Originator) |
Biological Testing |
Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Epigenetic Modifier Modulators |
Drug Conjugates PROTACs (Proteolysis Targeting Chimeras) |
Cancer | China Pharmaceutical University (Originator) |
Biological Testing |
Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Epigenetic Modifier Modulators |
Drug Conjugates PROTACs (Proteolysis Targeting Chimeras) |
Cancer | China Pharmaceutical University (Originator) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
CRBN-Targeted Drug Information-2
Table 3. Clinical drug targeting CRBN.
Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
Preclinical |
Drugs Targeting Protein Cereblon (CRBN) Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A (GSPT1) Degradation Inducers Myc Proto-Oncogene Protein (c-Myc) Degradation Inducers N-Myc Proto-Oncogene Protein (MYCN) Degradation Inducers Signal Transduction Modulators |
Molecular Glue Degraders | Cancer | Kintor (Originator) |
Preclinical |
Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1 Degradation Inducers Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1/Protein Cereblon (CRBN) Interaction Inducers Drugs Targeting Protein Cereblon (CRBN) Signal Transduction Modulators |
Molecular Glue Degraders | Cancer, prostate | Biolexis Therapeutics (Originator) |
Preclinical |
Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1 Degradation Inducers Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1/Protein Cereblon (CRBN) Interaction Inducers Drugs Targeting Protein Cereblon (CRBN) Signal Transduction Modulators |
Molecular Glue Degraders | Cancer, prostate | Biolexis Therapeutics (Originator) |
Preclinical |
Drugs Targeting Protein Cereblon (CRBN) GTPase KRAS (Gly12Asp Mutant) Degradation Inducers Signal Transduction Modulators |
PROTACs (Proteolysis Targeting Chimeras) | Cancer | Risen (Shanghai) Medical Technology (Originator) |
Preclinical |
Drugs Targeting Protein Cereblon (CRBN) Zinc Finger Protein Eos (IKZF4) Degradation Inducers Zinc Finger Protein Helios (IKZF2) Degradation Inducers Zinc Finger Protein Helios (IKZF2)/Protein Cereblon (CRBN) Interaction Inducers |
Molecular Glue Degraders | Cancer, solid tumor | SK Life Science Labs (Originator) |
Preclinical |
CDK2/Cyclin E1 Inhibitors CDK9/Cyclin T1 Inhibitors Cyclin-Dependent Kinase 1 (CDK1) Degradation Inducers Cyclin-Dependent Kinase 2 (CDK2) Degradation Inducers Cyclin-Dependent Kinase 2 (CDK2)/Protein Cereblon (CRBN) Interaction Inducers Drugs Targeting Protein Cereblon (CRBN) Signal Transduction Modulators |
Molecular Glue Degraders | Cancer | Plexium (Originator) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Creative Biolabs is a leader in antibody innovation, merging deep scientific knowledge with extensive practical experience to provide high-quality, cost-effective anti-CRBN antibodies. Our diverse selection of anti-CRBN antibody products is designed to support and elevate your research projects. For more details about our offerings and how they can benefit your studies, please don't hesitate to contact us.