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Anti-CRBN Recombinant Antibody Products

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Anti-CRBN Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is a top provider of high-quality reagents and services for life science researchers. Our comprehensive line of anti-CRBN antibody products demonstrates our dedication to quality. These antibodies are meticulously engineered to ensure optimal specificity, sensitivity, and reproducibility, making them invaluable tools for researchers investigating the role of CRBN in various biological processes, particularly in the context of cancer research.

CRBN: A Prospective Therapeutic Target for Cancer

Cereblon (CRBN), a protein involved in the ubiquitin-proteasome system, has emerged as a promising target for cancer therapy. Its unique ability to interact with small molecules and induce the degradation of specific proteins offers a novel approach to treating various cancers. While the field of CRBN-based cancer therapy is still in its early stages, the initial findings suggest that it may offer a valuable addition to the therapeutic armamentarium for patients with cancer. Continued research and development are required to fully realize the promise of this intriguing method.

Alternative Names

Cereblon; MRT2; MRT2A.

Background

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Transporters

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Low cell line specificity

Interaction

Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts directly with DDB1 (PubMed:25043012, PubMed:25108355). Interacts (in pomalidomide-bound form) with IKZF1 and IKZF3 (PubMed:24328678). Interacts with ILF2 (PubMed:33009960).

More Types Infomation

Anti-CRBN rAb Products

Creative Biolabs presents a diverse selection of high-quality anti-CRBN antibodies, expertly designed for exceptional performance across various research applications. Our rigorously validated reagents guarantee outstanding specificity, sensitivity, and reproducibility, empowering researchers to delve into the complexities of CRBN biology. With multiple formats and customization options, we equip you with the essential tools to advance your research and make significant discoveries.

Table 1. Featured anti-CRBN recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MOB-3265z Mouse Anti-CRBN Recombinant Antibody (clone 8C1) Human Mouse IgG1 WB, IHC, ELISA

Creative Quality Control

Creative Biolabs offers an extensive selection of premium anti-CRBN antibodies, each rigorously tested to ensure top performance across various applications. Our commitment to quality ensures that our products adhere to the highest industry standards, delivering reliable and consistent results to support your research endeavors.

Customer Reviews

Excellent
Me***g
Mouse Anti-CRBN Recombinant Antibody (clone 8C1) (MOB-3265z)
As a researcher studying the ubiquitin-proteasome system, I've relied heavily on Creative Biolabs' anti-CRBN antibodies for my experiments. The antibodies have been invaluable in characterizing the interactions between CRBN and its target proteins, providing essential insights into the mechanisms underlying various cellular processes. The versatility of these antibodies has allowed me to apply them in a wide range of techniques, including WB, IHC, and ELISA.
17/Apr/2023
Excellent
Qu***a
Mouse Anti-CRBN Recombinant Antibody (clone 8C1) (MOB-3265z)
Creative Biolabs' anti-CRBN antibodies have been indispensable in our ongoing research into multiple myeloma. The exceptional quality and performance of these reagents have consistently enabled us to achieve reproducible and reliable results. The high specificity and sensitivity of the antibodies have been particularly valuable in elucidating the intricate role of CRBN in disease pathogenesis and therapeutic response.
7/Nov/2023

rAb Production

Creative Biolabs' cutting-edge recombinant antibody platform harnesses the power of genetic engineering to create high-quality anti-CRBN antibodies. This novel technique enables efficient and adjustable manufacturing, assuring a continuous supply of antibodies suited to the unique demands of researchers across disciplines.

Featured Anti-CRBN Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-CRBN recombinant antibody production.

Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-CRBN recombinant antibody production.

rAb Modalities

Creative Biolabs delivers a large assortment of high-quality anti-CRBN recombinant antibodies available in a variety of forms to meet your individual research requirements.

Fig.3 CRBN antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-CRBN recombinant antibody production and modalities.

CRBN-Targeted Drug Information-1

Table 2. Public drug targeting CRBN.

Highest Phase Mechanism of Action Product Category Condition Organization
Biological Testing Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers
Drugs Targeting Protein Cereblon (CRBN)
Epigenetic Modifier Modulators
Drug Conjugates
PROTACs (Proteolysis Targeting Chimeras)
Cancer China Pharmaceutical University (Originator)
Biological Testing Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers
Drugs Targeting Protein Cereblon (CRBN)
Epigenetic Modifier Modulators
Drug Conjugates
PROTACs (Proteolysis Targeting Chimeras)
Cancer China Pharmaceutical University (Originator)
Biological Testing Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers
Drugs Targeting Protein Cereblon (CRBN)
Epigenetic Modifier Modulators
Drug Conjugates
PROTACs (Proteolysis Targeting Chimeras)
Cancer China Pharmaceutical University (Originator)
Biological Testing Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers
Drugs Targeting Protein Cereblon (CRBN)
Epigenetic Modifier Modulators
Drug Conjugates
PROTACs (Proteolysis Targeting Chimeras)
Cancer China Pharmaceutical University (Originator)
Biological Testing Bromodomain-Containing Protein 4 (BRD4; HUNK1) Degradation Inducers
Drugs Targeting Protein Cereblon (CRBN)
Epigenetic Modifier Modulators
Drug Conjugates
PROTACs (Proteolysis Targeting Chimeras)
Cancer China Pharmaceutical University (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

CRBN-Targeted Drug Information-2

Table 3. Clinical drug targeting CRBN.

Highest Phase Mechanism of Action Product Category Condition Organization
Preclinical Drugs Targeting Protein Cereblon (CRBN)
Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A (GSPT1) Degradation Inducers
Myc Proto-Oncogene Protein (c-Myc) Degradation Inducers
N-Myc Proto-Oncogene Protein (MYCN) Degradation Inducers
Signal Transduction Modulators
Molecular Glue Degraders Cancer Kintor (Originator)
Preclinical Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1 Degradation Inducers
Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1/Protein Cereblon (CRBN) Interaction Inducers
Drugs Targeting Protein Cereblon (CRBN)
Signal Transduction Modulators
Molecular Glue Degraders Cancer, prostate Biolexis Therapeutics (Originator)
Preclinical Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1 Degradation Inducers
Cyclin-Dependent Kinase 9 (CDK9)/Cyclin T1/Protein Cereblon (CRBN) Interaction Inducers
Drugs Targeting Protein Cereblon (CRBN)
Signal Transduction Modulators
Molecular Glue Degraders Cancer, prostate Biolexis Therapeutics (Originator)
Preclinical Drugs Targeting Protein Cereblon (CRBN)
GTPase KRAS (Gly12Asp Mutant) Degradation Inducers
Signal Transduction Modulators
PROTACs (Proteolysis Targeting Chimeras) Cancer Risen (Shanghai) Medical Technology (Originator)
Preclinical Drugs Targeting Protein Cereblon (CRBN)
Zinc Finger Protein Eos (IKZF4) Degradation Inducers
Zinc Finger Protein Helios (IKZF2) Degradation Inducers
Zinc Finger Protein Helios (IKZF2)/Protein Cereblon (CRBN) Interaction Inducers
Molecular Glue Degraders Cancer, solid tumor SK Life Science Labs (Originator)
Preclinical CDK2/Cyclin E1 Inhibitors
CDK9/Cyclin T1 Inhibitors
Cyclin-Dependent Kinase 1 (CDK1) Degradation Inducers
Cyclin-Dependent Kinase 2 (CDK2) Degradation Inducers
Cyclin-Dependent Kinase 2 (CDK2)/Protein Cereblon (CRBN) Interaction Inducers
Drugs Targeting Protein Cereblon (CRBN)
Signal Transduction Modulators
Molecular Glue Degraders Cancer Plexium (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is a leader in antibody innovation, merging deep scientific knowledge with extensive practical experience to provide high-quality, cost-effective anti-CRBN antibodies. Our diverse selection of anti-CRBN antibody products is designed to support and elevate your research projects. For more details about our offerings and how they can benefit your studies, please don't hesitate to contact us.

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