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CRHBP
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For Research Use Only. Not For Clinical Use.
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Protein class
Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Hepatic stellate cells, Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced
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