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CSH2

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity.
Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Syncytiotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, SuSa)

Interaction

Can be found in a monomeric as well as dimeric form.

Molecular function

Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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