Anti-CSNK2A2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in oncology and cell biology and offers a portfolio of highly specific anti-CSNK2A2 recombinant antibodies. CSNK2A2 is the alpha-prime catalytic subunit of the CK2 kinase, with many overlapping and some unique functions compared to the alpha isoform. We have developed premium antibodies to help you dissect the complex biology of this CK2 complex and fully understand its role in cancer.

CSNK2A2: The Alpha-Prime Catalytic Subunit of CK2

Casein Kinase 2 Alpha 2 (CSNK2A2) is the second catalytic subunit of the protein kinase CK2, also known as CK2-alpha prime. It is highly homologous to the more abundant CSNK2A1 subunit and will readily assemble with regulatory beta subunits to form an active CK2 holoenzyme. CSNK2A2 has been shown to phosphorylate many of the same substrates as CSNK2A1; however, it also has distinct substrates and non-redundant roles in certain processes such as spermatogenesis. Furthermore, studies indicate that it has non-redundant roles in certain cancers as well. The specific contribution of CSNK2A2-containing CK2 complexes to physiological and disease-related processes is an active area of study, and dissection of this will be necessary to fully understand the biology of this master kinase.

Alternative Names

CSNK2A2; CK II Alpha; EC 2.7.11.1; CK2A2; CSNK2A1; Casein Kinase 2, Alpha Prime Polypeptide; Casein Kinase II Subunit Alpha

Background

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Anti-CSNK2A2 rAb Products

Creative Biolabs' anti-CSNK2A2 recombinant antibodies are designed to provide you with an antibody of the highest specificity. They are thoroughly validated to specifically detect the alpha-prime subunit and not cross-react with the highly homologous and more abundant CSNK2A1 subunit. This isoform specificity is key to being able to specifically study the functions of this subunit. They are optimized for use in applications such as IHC and Western Blot and will provide clear, unambiguous results.

Table 1. Featured anti-CSNK2A2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs leverages the latest technologies in recombinant antibody production to provide solutions for specialized fields like cell biology. Our anti-CSNK2A2 recombinant antibodies are expressed in systems that are optimized to ensure that they will accurately recognize the native enzyme and provide you with a highly specific and active tool for your experiments.

Featured Anti-CSNK2A2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CSNK2A2 recombinant antibody production.

Fig.2 Gram-scale anti-CSNK2A2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting your research and discovery by offering you flexible and customizable solutions. Our anti-CSNK2A2 recombinant antibodies are available in a variety of formats that you can customize to your exact specifications, allowing researchers worldwide to study this important kinase subunit.

Fig.3 Full-length anti-CSNK2A2 recombinant antibody production and modalities.

Creative Biolabs recombinant antibodies are perfect for dissecting the specific functions of CK2 alpha-prime. We are defined by the high quality of our antibodies and strict validation and testing to guarantee high specificity. Let us help you choose the perfect tool for your research into the complex biology of CK2 signaling. Get in touch with our specialists today.