Anti-CSNK2B Recombinant Antibody Products

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Anti-CSNK2B Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is your premier provider of signal transduction research tools and world-class anti-CSNK2B recombinant antibodies. As the non-catalytic regulatory subunit of the CK2 kinase complex, CSNK2B plays a pivotal role in determining the enzyme’s stability, substrate specificity, and overall activity. Our premium quality antibodies are indispensable in probing the assembly and regulation of the CK2 “master kinase” and its involvement in human pathology.

CSNK2B: The Regulatory Hub of the CK2 Kinase

Casein Kinase 2 Beta, known as CSNK2B, is the regulatory subunit of the serine/threonine protein kinase CK2. It is an obligate dimer that serves as the core of the heterotetrameric CK2 holoenzyme by binding two catalytic subunits, either alpha or alpha-prime. Although it has no enzymatic activity, CSNK2B is indispensable for the function of CK2. It confers a dramatic increase in stability and activity of the catalytic subunits and, importantly, tunes their substrate specificity to target key proteins for phosphorylation. It also serves as a protein docking site for other signaling molecules, embedding CK2 in complex cellular networks.

Alternative Names

Casein Kinase 2 Beta; Casein Kinase 2, Beta Polypeptide; Protein G5a; CK II Beta; Phosvitin; CK2N; G5A; Casein Kinase II B Subunit Splicing Isoform 132; Casein Kinase II B Subunit Splicing Isoform 247; Casein Kinase II B Subunit Splicing Isoform 318; Casein Kinase II B Subunit Splicing Isoform 660; Casein Kinase II B Subunit Splicing Isoform 806; Chimera CSNK2B-LY6G5B Splicing Isoform 1072; Chimera CSNK2B-LY6G5B Splicing Isoform 1103; Chimera CSNK2B-LY6G5B Splicing Isoform 532;

Background

CSNK2B (Casein Kinase 2 Beta) is a Protein Coding gene. Diseases associated with CSNK2B include Autosomal Dominant Non-Syndromic Intellectual Disability and Egg Allergy. Among its related pathways are Mitotic Prometaphase and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include identical protein binding and receptor binding.

Protein class

Cancer-related genes, Disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with DYNLT2 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

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Anti-CSNK2B rAb Products

Our anti-CSNK2B recombinant antibodies are designed for unmatched specificity and performance. Each antibody is thoroughly validated to ensure it specifically detects the beta subunit of the CK2 complex. Optimized for a variety of applications, including Western Blot to determine expression and co-immunoprecipitation to study assembly of the full CK2 holoenzyme and its interactome, our rAbs provide the specificity and activity you need for your research.

Table 1. Featured anti-CSNK2B recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MRO-0394-CN Rabbit Anti-CSNK2B Recombinant Antibody (clone JU37-62) Human, Mouse, Rat Rabbit IgG WB, IHC, IP
VS3-WK81 Mouse Anti-CSNK2B Recombinant Antibody (clone F3-F12) Human Mouse IgG1 WB, ICC, IHC, FC
MOB-2333z Mouse Anti-CSNK2B Recombinant Antibody (clone 22A2) Human Mouse IgG1 WB, ELISA, FC, ICC, IHC

Customer Reviews

Excellent
C**ra
The anti-CSNK2B antibody from Creative Biolabs was a game changer in our research. We used it to co-immunoprecipitate the full CK2 complex out of cell lysates for functional analysis.
16/Sep/2024

rAb Production

Creative Biolabs is dedicated to advancing the niche field of cell signaling research with the highest quality products and services. Our production platforms are equipped with state-of-the-art technologies and our anti-CSNK2B recombinant antibodies are expressed in optimized systems so we can be sure they will recognize the native protein. This approach guarantees a highly specific and active antibody for your research.

Featured Anti-CSNK2B Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-CSNK2B recombinant antibody production.

Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-CSNK2B recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific discoveries with flexible antibody solutions. Our anti-CSNK2B recombinant antibodies are available in a range of customizable formats so we can help researchers from around the world study this important regulatory protein in any application you need.

Fig.3 CSNK2B antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-CSNK2B recombinant antibody production and modalities.

Probe the vital regulation of the CK2 kinase with Creative Biolabs’ superior quality anti-CSNK2B recombinant antibodies. We are defined by our commitment to providing the highest quality antibodies and each of our products has been rigorously validated for specificity and performance, making them ideal tools for your research. Trust us for quality that will advance your discoveries. Reach out to our team today.

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