Anti-CSTB Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a Neuroscience and Rare Disease research specialist and your source for premium anti-CSTB recombinant antibodies. Cystatin B (CSTB) is a major and essential inhibitor of cysteine proteases and modulates lysosomal function. We offer recombinant antibodies that are essential research tools for dissecting the molecular cause of progressive myoclonus epilepsy (EPM1) and for monitoring lysosomal enzyme activities.

CSTB: The Inhibitor Deficient in Unverricht-Lundborg Disease

Cystatin B (CSTB) is a small, ubiquitously expressed, cytosolic cysteine protease inhibitor. CSTB primarily protects cells against unwanted degradation by inhibiting the activity of lysosomal cysteine cathepsins (Cathepsin B, L, and S), which can leak into the cytoplasm. CSTB is predominantly localized to the cytoplasm and nucleus and is expressed highest in the brain. Loss-of-function mutations in the CSTB gene result in Unverricht-Lundborg disease (EPM1), a progressive form of myoclonus epilepsy. Disease pathology has been attributed to the unregulated activities of Cathepsins, particularly in neurons, which may lead to increased apoptosis and inflammation.

Alternative Names

CSTB; STFB; Liver Thiol Proteinase Inhibitor; EPM1A; PME; Cystatin-B; CST6; Stefin-B; Cystatin B (Stefin B); ULD

Background

CSTB (Cystatin B) is a Protein Coding gene. Diseases associated with CSTB include Myoclonic Epilepsy Of Unverricht and Lundborg and Unverricht-Lundborg Syndrome. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include endopeptidase inhibitor activity. An important paralog of this gene is CSTA.

Anti-CSTB rAb Products

Creative Biolabs anti-CSTB recombinant antibodies are developed with a strong focus on specificity and performance. Meticulously validated, our CSTB antibodies will allow you to reliably detect the CSTB protein. Optimized for Western Blot to validate EPM1 diagnosis in patient derived fibroblasts or IHC to study its expression and distribution in the brain, our rAbs will give you the performance you need for your neuroscience research.

Table 1. Featured anti-CSTB recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is dedicated to the integrity of scientific research. The production of our anti-CSTB recombinant antibodies is backed by a rigorous quality assurance framework. Each lot is tested for purity and specificity, as well as stringent quality control for consistent performance in our validated applications. We guarantee you will receive a reliable and robust reagent from us.

Customer Reviews

rAb Production

We offer the entire production platform required to support the highly specialized field of rare disease research. Our anti-CSTB recombinant antibodies are expressed in highly optimized systems that produce antibodies that recognize the native protein with high fidelity to ensure a specific and active tool.

Featured Anti-CSTB Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CSTB recombinant antibody production.

Fig.4 Gram-scale anti-CSTB recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to empowering scientists in pursuit of scientific discovery. We offer a wide range of flexible antibody modalities to meet your specific research needs. Our anti-CSTB recombinant antibodies are available in various customizable formats.

Fig.5 Full-length anti-CSTB recombinant antibody production and modalities.

Creative Biolabs is a Neuroscience and Rare Disease research specialist and your source for premium anti-CSTB recombinant antibodies. Trust our expertise to give you a solid foundation for your research. Contact our specialists today.