Anti-CTBP1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leading provider of anti-CTBP1 recombinant antibodies, enabling breakthrough research in oncology and signal transduction. C-Terminal Binding Protein 1 (CTBP1) is a well-established transcriptional co-repressor, which acts as a sensor of the cell's metabolic status to suppress differentiation programs and promote epithelial-mesenchymal transition (EMT). Our high-quality antibodies are a vital tool to study its function in cancer metastasis and gene silencing.

CTBP1: A Metabolic Sensor of Transcriptional Repression

C-Terminal Binding Protein 1 (CTBP1) is a nuclear transcriptional co-repressor that is recruited to DNA by direct binding to the C-terminus of zinc finger transcription factors (such as repressors of E-cadherin). CTBP1 itself can then recruit histone deacetylases (HDACs) and methyltransferases to the DNA, resulting in chromatin condensation, and ultimately, silencing of tumor suppressor genes and differentiation programs. However, what is unique about CTBP1 is its ability to bind the metabolic intermediate NADH. As a result, the repressor activity of CTBP1 is directly coupled to the redox state of the cell, creating a metabolic-to-epigenetic regulatory axis. CTBP1 is therefore an important driver of the EMT and metastasis in cancer.

Alternative Names

C-Terminal Binding Protein 1; Brefeldin A-Ribosylated Substrate; C-Terminal-Binding Protein 1; EC 1.1.1.158; EC 1.1.1.-; EC 1.1.1; CtBP1; BARS; CTBP;

Background

CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Diseases associated with CTBP1 include Chromosome 4P Deletion and Colon Adenoma. Among its related pathways are Ectoderm Differentiation and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is CTBP2.

Anti-CTBP1 rAb Products

The anti-CTBP1 recombinant antibodies we offer have been optimized for specific detection of the CTBP1 protein in nuclear extracts. Our rAbs have been rigorously validated in a range of applications, including Western Blot, IHC, and Chromatin Immunoprecipitation (ChIP) to provide clarity and precision for high-impact research into gene silencing.

Table 1. Featured anti-CTBP1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to helping researchers make progress in the fight against cancer, and that is why we have embraced some of the latest technologies for producing research antibodies. Our anti-CTBP1 recombinant antibodies are expressed in systems that have been optimized to ensure the antibody precisely recognizes the native protein, to provide you with a highly specific and active research tool.

Featured Anti-CTBP1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CTBP1 recombinant antibody production.

Fig.2 Gram-scale anti-CTBP1 recombinant antibody production.

rAb Modalities

Creative Biolabs is proud to provide our customers with innovative and flexible solutions for their cancer research. Our anti-CTBP1 recombinant antibodies are available in a variety of formats, all of which are customizable to your specific needs. This allows us to empower researchers around the world to explore the function of this important transcriptional co-repressor.

Fig.3 Full-length anti-CTBP1 recombinant antibody production and modalities.

Explore the functions of CTBP1 in cancer metastasis with Creative Biolabs' recombinant antibodies. Our products stand out through our rigorous validation and high consistency, providing you with the best tools to study this important metabolic regulator of transcription. Contact us today and partner with a company that prioritizes quality to drive your research forward.