CTNNB1 Phosphorylation

CTNNB1, encoding β-catenin, is a multifunctional protein that plays a dual and critical role in cellular biology: it acts as a central component of cadherin-based adherens junctions for cell-cell adhesion and is the key effector molecule of the canonical Wnt signaling pathway, regulating gene transcription. The tight regulation of β-catenin's stability and subcellular localization, predominantly controlled by its phosphorylation status, is therefore paramount for maintaining cellular homeostasis, development, and preventing disease.