Anti-CTNS Products

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For Research Use Only. Not For Clinical Use.

Best In Class for lysosomal storage disease research, Creative Biolabs provides premium anti-CTNS recombinant antibodies. Cystinosin (CTNS), the lysosomal cystine transporter, plays a crucial role in removing the amino acid cystine from the lysosome. Our high-quality recombinant antibodies (rAbs) are a powerful diagnostic tool to test for cystinosis, and a high-confidence reagent to help uncover novel therapies for this devastating genetic disease.

CTNS: The Lysosomal Cystine Efflux Pump

Cystinosin (CTNS) is a multi-pass transmembrane protein found on the lysosome's membrane. Its primary role is to transport the amino acid cystine out of the lysosome and into the cytoplasm, where it can be used normally by the cell's metabolism. The lysosome degrades proteins into amino acids, which are then typically exported. When loss-of-function mutations in the CTNS gene inactivate this transporter, cystine accumulates in the lysosome as toxic crystals. This lysosomal storage disorder is called cystinosis and leads to widespread tissue damage. The most severely damaged organs are the kidneys (Fanconi syndrome) and the eyes.

Alternative Names

Cystinosin, Lysosomal Cystine Transporter; Cystinosis, Nephropathic; Cystinosis Nephropathic; Cystinosin; CTNS-LSB; PQLC4

Background

CTNS (Cystinosin, Lysosomal Cystine Transporter) is a Protein Coding gene. Diseases associated with CTNS include Cystinosis, Nephropathic and Cystinosis, Late-Onset Juvenile Or Adolescent Nephropathic Type. Among its related pathways are Lysosome and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include L-cystine transmembrane transporter activity.

Anti-CTNS rAb Products

Creative Biolabs' anti-CTNS recombinant antibodies are designed to perform with unparalleled specificity and stability. Our rigorous validation ensures they accurately detect the Cystinosin protein. Optimized for applications such as immunofluorescence to validate its lysosomal localization and Western Blot for the diagnosis of the deficiency, our recombinant antibodies (rAbs) deliver the reliability and precision that you need for advanced metabolic studies.

Table 1. Featured anti-CTNS recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs understands the critical role of rare disease research and supports this challenging field with the latest in production platforms. Our anti-CTNS recombinant antibodies are expressed in systems that are optimized to produce reagents that accurately recognize the native protein to ensure you receive a very specific and active tool for your studies.

Featured Anti-CTNS Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CTNS recombinant antibody production.

Fig.2 Gram-scale anti-CTNS recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting new scientific discoveries by providing the most flexible antibody solutions possible. Our anti-CTNS recombinant antibodies are available in a variety of modalities that can be customized to meet your unique needs.

Fig.3 Full-length anti-CTNS recombinant antibody production and modalities.

Probe the biology of lysosomal transport using only the most selective and stable reagents, like Creative Biolabs' premium anti-CTNS recombinant antibodies. Our portfolio is designed to provide the thorough validation and consistency that is needed to study this important transporter. Let our experts give your work the best start possible. Contact us today!