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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (NK-cells, dendritic cells, T-cells)
Immune cell specificity
Group enriched (NK-cell, gdT-cell, memory CD8 T-cell, MAIT T-cell, naive CD8 T-cell)
Cell line specificity
Group enriched (HEL, NB-4)
Molecular function
Hydrolase, Protease, Thiol protease
More Types Infomation