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CUL2
Anti-CUL2 Recombinant Antibody Products
- Rabbit Anti-CUL2 Recombinant Antibody (clone JG72-31) (MRO-0403-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP
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- Anti-CUL2 Immunohistochemistry Kit (VS-0325-XY585)
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- Species Reactivity: Human, Mouse, Rat
- Target: CUL2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
CUL2 (Cullin 2) is a Protein Coding gene. Diseases associated with CUL2 include Hypoxia and Von Hippel-Lindau Syndrome. Among its related pathways are Innate Immune System and ErbB signaling pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and protein complex binding. An important paralog of this gene is CUL1.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and a variable substrate-specific adapter (PubMed:9122164, PubMed:10973499, PubMed:11384984, PubMed:26138980, PubMed:29779948, PubMed:29775578). Component of the ECS(VHL) or CBC(VHL) complex containing VHL (PubMed:9122164, PubMed:10973499, PubMed:11384984). Component of the ECS(MED8) complex with the probable substrate recognition component MED8 (PubMed:12149480). Component of multiple ECS complexes part of the DesCEND (destruction via C-end degrons) pathway, which contain either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component (PubMed:23102700, PubMed:26138980, PubMed:29779948, PubMed:29775578). Component of the ECS(LRR1) complex with the probable substrate recognition component LRR1 (PubMed:15601820). Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, ELOB, ELOC and FEM1B (PubMed:15601820). Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC (PubMed:17304241). Part of an E3 ubiquitin-protein ligase complex including ZER1, CUL2 and Elongin BC (PubMed:17304241). Interacts with RBX1, RNF7, FEM1B and TIP120A/CAND1 (PubMed:10230407, PubMed:12609982). Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2 (PubMed:22286099). Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655, PubMed:27565346). Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation (PubMed:23401859, PubMed:23201271, PubMed:24192928, PubMed:26906416). Component of VCB (elongins BC/CUL2/VHL) complex that contains at least DCUN1D1, CUL2 and VHL; this complex triggers CUL2 neddylation and consequently cullin ring ligase (CRL) substrates polyubiquitylation (PubMed:23401859). (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.
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