Anti-CYP2C19 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a pharmaceutical and precision medicine innovator. These are our best-in-class anti-CYP2C19 recombinant antibodies. CYP2C19 is a highly polymorphic enzyme, the expression and activity of which is a strong predictor of patient response to major classes of drugs such as antiplatelet drug clopidogrel and antidepressants. Our top-notch anti-CYP2C19 antibodies are powerful tools to study its pharmacogenomics as well as validate the drug metabolism in the general population.

CYP2C19: A Key Polymorphic Drug Metabolizer

Cytochrome P450 2C19 (CYP2C19) is a monooxygenase enzyme present in the endoplasmic reticulum of liver cells. This enzyme has an extremely high genetic polymorphism, which segregates the population into poor, intermediate, extensive, and ultrarapid metabolizers. It is a major human drug metabolizer and is responsible for processing about 15% of the drugs in clinical use. These include drugs like proton pump inhibitors (PPIs) and most importantly the anti-platelet pro-drug clopidogrel (Plavix). Non-active form of clopidogrel needs to be converted into its active form by CYP2C19 enzyme. Poor metabolizers of clopidogrel (carrying gene variants) are unable to activate the drug properly, which increases their risk of heart attack and stroke manyfold. This is why CYP2C19 is a textbook example of a pharmacogenomic target.

Alternative Names

CYP2C19; P450C2C; S-Mephenytoin 4-Hydroxylase; EC 1.14.13.-; Mephenytoin 4-Hydroxylase; Cytochrome P450 2C19; Cytochrome P450-11A; (S)-Limonene 7-Monooxygenase; (S)-Limonene 6-Monooxygenase; EC 1.14.13.80; Microsomal Monooxygenase; (R)-Limonene 6-Monooxyg

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Anti-CYP2C19 rAb Products

Our recombinant antibodies specific to CYP2C19 are tailor-made to be extremely specific to the enzyme of interest. They are comprehensively validated to ensure that they only detect the target CYP2C19 enzyme and not the homologous enzyme CYP2C9. Optimized for applications like Western Blot of liver microsomes and IHC, our rAbs can provide you the accuracy and specificity that your study requires.

Table 1. Featured anti-CYP2C19 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs' state-of-the-art antibody production platforms have been designed keeping in mind the needs of cutting-edge research areas like clinical pharmacology. Our anti-CYP2C19 recombinant antibodies are expressed in optimized systems that ensure that they recognize the native enzyme in the right way to guarantee a very specific and functional tool.

Featured Anti-CYP2C19 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CYP2C19 recombinant antibody production.

Fig.2 Gram-scale anti-CYP2C19 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to enabling scientific innovation by providing customizable antibody solutions for the scientist. Our recombinant anti-CYP2C19 antibodies come in a range of customizable modalities to give you the flexibility you need.

Fig.3 Full-length anti-CYP2C19 recombinant antibody production and modalities.

Decipher the mechanisms of drug metabolism with ultra-high precision using the best-in-class anti-CYP2C19 recombinant antibodies from Creative Biolabs. Our portfolio of recombinant antibodies against this important enzyme have the validation and specificity your research demands. Place your work on a reliable foundation by choosing Creative Biolabs today. Talk to our experts.