Anti-CYP2C8 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs supplies top-of-the-line anti-CYP2C8 recombinant antibodies for high-end pharmacology research and drug metabolism assays. A critical enzyme that catalyzes both drug-drug interactions and lipid metabolism, CYP2C8 is one of the primary liver enzymes that metabolizes key medications such as taxanes, cerivastatin and related drugs, as well as fatty acids. Obtain highly-validated, specific anti-CYP2C8 reagents to study its pharmacogenomics, or to monitor its expression in studies of lipid signaling metabolism.

CYP2C8: A Major Metabolizer of Lipids and Taxanes

Cytochrome P450 2C8 (CYP2C8) is a monooxygenase enzyme expressed in liver and small intestine. As one of the principal CYP450 enzymes, CYP2C8 is a major catalyst for the phase I metabolism of a number of clinically used drugs, particularly the anti-cancer taxane drugs (paclitaxel, docetaxel) and lipid lowering statin drugs (cerivastatin). In endogenous lipid metabolism, CYP2C8 generates epoxyeicosatrienoic acids (EETs) from arachidonic acid, which have potent vasodilator and anti-inflammatory activity. CYP2C8 is widely distributed in body tissues, and due to its extensive substrate range, plays a key role in determining both drug toxicity and drug efficacy.

Alternative Names

CYP2C8; Xenobiotic Monooxygenase; Cytochrome P450 MP-20; MP-12/MP-20; Cytochrome P450 MP-12; Cytochrome P450, Family 2, Subfamily C, Polypeptide 8; Microsomal Monooxygenase; Flavoprotein-Linked Monooxygenase; Cytochrome P450 Form 1; S-Mephenytoin 4-Hydrox

Background

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Anti-CYP2C8 rAb Products

To meet high standards for specificity, our anti-CYP2C8 recombinant antibodies are engineered to precisely target the enzyme. Each product is rigorously validated in applications such as Western Blot of liver microsomes, IHC and immunoprecipitation to rule out cross-reactivity with other closely related CYP2C family members and to ensure accurate detection of CYP2C8 protein.

Table 1. Featured anti-CYP2C8 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has embraced the latest advances in antibody production technology to offer the best possible solutions to the scientific community. We have fully optimized, automated platforms for antibody expression, and our anti-CYP2C8 recombinant antibodies are expressed in carefully chosen and validated systems to ensure recognition of the native protein and produce a specific and active antibody.

Featured Anti-CYP2C8 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CYP2C8 recombinant antibody production.

Fig.2 Gram-scale anti-CYP2C8 recombinant antibody production.

rAb Modalities

Creative Biolabs is always exploring new ways to support cutting-edge science by offering the best antibody solutions for researchers. Our anti-CYP2C8 recombinant antibodies are available in a variety of modalities, allowing you to select and customize exactly what you need for your experiments.

Fig.3 Full-length anti-CYP2C8 recombinant antibody production and modalities.

Explore drug metabolism with the precision of Creative Biolabs' top-quality, high specificity anti-CYP2C8 recombinant antibodies. Our validated portfolio of antibodies provides a robust foundation for your research on this important enzyme and its role in drug metabolism and pharmacogenomics. Let our team of specialists help you find the ideal antibody for your research. Contact us today.