Anti-CYP3A7 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, your partner in developmental and cancer research, is pleased to offer you its premium anti-CYP3A7 recombinant antibodies. A major player in the fetal period, CYP3A7 is the main CYP3A enzyme expressed in the developing liver, and is a major contributor to fetal drug metabolism and endogenous compound clearance. Our high quality antibodies are an ideal research tool to help you investigate the enzyme's role in fetal drug metabolism as well as its dysregulated re-expression in some adult cancers.

CYP3A7: The Fetal Drug Metabolizer

Cytochrome P450 3A7 (CYP3A7) is an endoplasmic reticulum-based monooxygenase enzyme, and is the main isoform of the CYP3A family found in human fetal liver. Expression of this gene is rapidly downregulated at birth, and is replaced by expression of the adult isoform, CYP3A4. CYP3A7 is responsible for the metabolism of many fetal steroids as well as maternal drugs that can pass through the placental barrier. The gene is silenced in the adult liver, but can be aberrantly re-expressed in certain malignancies (such as hepatocellular carcinoma) where it is associated with a fetal metabolic phenotype.

Alternative Names

Cytochrome P450 Family 3 Subfamily A Member 7; Cytochrome P450, Family 3, Subfamily A, Polypeptide 7; Cytochrome P450, Subfamily IIIA, Polypeptide 7; Cytochrome P450-HFLA; EC 1.14.14.1; CYPIIIA7; Flavoprotein-Linked Monooxygenase; Aryl Hydrocarbon Hydroxylase

Background

CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP3A7-CYP3A51P.

Anti-CYP3A7 rAb Products

Creative Biolabs anti-CYP3A7 recombinant antibodies have been engineered to be highly specific. Validated to detect the CYP3A7 enzyme specifically, these antibodies were also tested for cross-reactivity with the adult isoform, CYP3A4. Our rAbs are optimized for Western Blot of fetal liver or tumor microsomes, and for IHC, giving you a reliable, validated research tool to provide the quality and specificity you need for your developmental or cancer research.

Table 1. Featured anti-CYP3A7 recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs we take our responsibility to science seriously, and our quality assurance program for our recombinant antibodies is designed with this commitment in mind. Validation of each lot of antibodies is a key part of our development process and includes a stringent set of quality control tests, including purity, isoform specificity, and performance in their validated applications.

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rAb Production

Creative Biolabs has invested in advanced production platforms to be able to support the highly specialized research area of developmental biology. Our anti-CYP3A7 recombinant antibodies are expressed in highly optimized systems to ensure that they specifically recognize the native protein, giving you a very specific and active research tool.

Featured Anti-CYP3A7 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CYP3A7 recombinant antibody production.

Fig.4 Gram-scale anti-CYP3A7 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting your scientific discoveries by giving you the most flexible solutions we can provide. Our recombinant antibodies are available in a number of customizable modalities.

Fig.5 Full-length anti-CYP3A7 recombinant antibody production and modalities.

Precisely dissect drug metabolism mechanisms using the best in class anti-CYP3A7 recombinant antibodies from Creative Biolabs. With a portfolio of validated, high quality antibodies, you can be sure to find a perfect tool to help you study this enzyme's role in fetal development and cancer. Don't take a chance with an unvalidated antibody, and trust us to provide you with a robust platform for your research. Contact our experts today.