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For Research Use Only. Not For Clinical Use.
Secreted
Cell type enhanced (Extravillous trophoblasts, Fibroblasts, Cytotrophoblasts, Adipocytes, Syncytiotrophoblasts, Cardiomyocytes)
Not detected in immune cells
Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, EFO-21, SiHa, TIME, U-251 MG)
Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.
Growth factor binding, Heparin-binding