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CYR61

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Fibroblasts, Cytotrophoblasts, Adipocytes, Syncytiotrophoblasts, Cardiomyocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, EFO-21, SiHa, TIME, U-251 MG)

Interaction

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

Molecular function

Growth factor binding, Heparin-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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