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DARS
Loading...Anti-DARS Recombinant Antibody Products
- Recombinant Mouse Anti-Human DARS Antibody (MOB-1075MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
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- AbPlus™ Anti-DARS Magnetic Beads (VS-0724-YC222) (VS-0724-YC222)
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- Target: DARS
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Extravillous trophoblasts, Syncytiotrophoblasts, Cytotrophoblasts, Hofbauer cells, Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:23609930). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464).
Molecular function
Aminoacyl-tRNA synthetase, Ligase
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