DCK
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Loading...- Chicken Anti-DCK Polyclonal IgY (BRD-0749MZ)
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- Species Reactivity: Human, Mouse
- Type: Chicken antibody
- Application: ELISA, IHC, IP, WB
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- Anti-DCK Immunohistochemistry Kit (VS-0325-XY626)
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- Species Reactivity: Human, Mouse, Rat
- Target: DCK
- Application: IHC
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- Anti-Mouse DCK Immunohistochemistry Kit (VS-0525-XY1919)
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- Species Reactivity: Human, Mouse, Rat, Monkey
- Target: DCK
- Application: IHC
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- Anti-Human DCK Immunohistochemistry Kit (VS-0525-XY1918)
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- Species Reactivity: Human
- Target: DCK
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, B-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, U-698)
Interaction
Homodimer.
Molecular function
Kinase, Transferase
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