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DCUN1D2
Anti-DCUN1D2 Recombinant Antibody Products
- AbPlus™ Anti-DCUN1D2 Magnetic Beads (VS-0724-YC579) (VS-0724-YC579)
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- Target: DCUN1D2
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
DCUN1D2 (Defective In Cullin Neddylation 1 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DCUN1D3.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Excitatory neurons, Oligodendrocytes, Inhibitory neurons)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (SCLC-21H)
Interaction
Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction (PubMed:26906416, PubMed:23201271, PubMed:19617556). May also interact with regulators or subunits of cullin-RING ligases such as RBX1, RNF7, ELOB and DDB1; these interactions are bridged by cullins (PubMed:26906416). Interacts with CAND1; this interaction is bridged by cullins such as CUL3 and strongly inhibits the neddylation of CUL3. These CAND-cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter (PubMed:26906416). Interacts (via DCUN1 domain) with the N-terminally acetylated form of UBE2M and UBE2F (PubMed:23201271, PubMed:19617556).
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