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DENND3
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For Research Use Only. Not For Clinical Use.
Background
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Microglial cells)
Immune cell specificity
Immune cell enhanced (neutrophil, eosinophil)
Cell line specificity
Cell line enhanced (HDLM-2, HeLa, U-937)
Interaction
Forms oligomers. Interacts with 6 of the 7 known isoforms of 14-3-3 proteins.
Molecular function
Guanine-nucleotide releasing factor
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