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DHCR24
Loading...Anti-DHCR24 Products
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Anti-DHCR24 Immunohistochemistry Kit (VS-0325-XY656)
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- Species Reactivity: Human, Mouse, Rat
- Target: DHCR24
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatocytes, Alveolar cells type 2, Theca cells, Alveolar cells type 1)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff)
Interaction
Interacts with DHCR7; this interaction regulates DHCR7 activity.
Molecular function
Oxidoreductase
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