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DMC1
Loading...Anti-DMC1 Products
- Mouse Anti-DMC1 Recombinant Antibody (clone 2H12/4) (FAMAB-1118CQ)
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- Species Reactivity: Bovine, Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: IP, WB, IF, IHC
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- Anti-DMC1 Immunohistochemistry Kit (VS-0325-XY675)
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- Species Reactivity: Human, Mouse, Rat
- Target: DMC1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Group enriched (Spermatocytes, Spermatogonia)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced
Interaction
Double stacked ring-shaped homooctamer (PubMed:15125839). Interacts with BRCA2 (PubMed:20729832). Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with RAD51AP1; the interaction is direct and stimulates DMC1-mediated homologous recombination (PubMed:21307306, PubMed:21903585).
Molecular function
DNA-binding
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