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DNAH8

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For Research Use Only. Not For Clinical Use.


Background

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Early spermatids, Spermatocytes, Late spermatids)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enriched (HMC-1)

Interaction

Consists of at least two heavy chains and a number of intermediate and light chains.

Molecular function

Motor protein

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