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Target
Application
Host
Species Reactivity
Conjugate
DNTTIP1
Anti-DNTTIP1 ProductsBackground
Anti-DNTTIP1 Products
- Anti-DNTTIP1 Immunohistochemistry Kit (VS-0525-XY2050)
-
- Species Reactivity: Human
- Target: DNTTIP1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (PC-3)
Interaction
Monomer and homodimer (PubMed:11473582, PubMed:25653165). A minor proportion may form homotrimers (PubMed:11473582). Interacts with ZNF541 (PubMed:21573134). Interacts with the terminal deoxynucleotidyltransferase DNTT (PubMed:11473582, PubMed:16371131). Interacts with TRERF1 (PubMed:16371131, PubMed:21573134). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and MIDEAS; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).
Molecular function
DNA-binding
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