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DRD4
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
Protein class
FDA approved drug targets, G-protein coupled receptors, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Group enriched (Rod photoreceptor cells, Bipolar cells, Cone photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Forms homo- and heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. and 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CLIC6 (By similarity). Interacts with GPRASP1 (PubMed:12142540). May interact with ADORA2A (PubMed:20836733). Interacts with KLHL12 (PubMed:18303015).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
- Mouse Anti-DRD4 Recombinant Antibody (MOB-3297z) (MOB-3297z)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, ELISA
- Recombinant Anti-Human DRD4 Antibody scFv Fragment (MOB-3297z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: Neut, IF, FuncS
- Recombinant Anti-Human DRD4 Antibody Fab Fragment (MOB-3297z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, WB, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.