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DTL
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Anti-DTL ProductsBackground
Anti-DTL Products
- Anti-DTL Immunohistochemistry Kit (VS-0525-XY2101)
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- Species Reactivity: Human
- Target: DTL
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
DTL (Denticleless E3 Ubiquitin Protein Ligase Homolog) is a Protein Coding gene. Diseases associated with DTL include Myasthenic Syndrome, Congenital, 8. Among its related pathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Erythroid cells, Early spermatids, Spermatogonia, Extravillous trophoblasts)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Component of the DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2)), at least composed of CUL4 (CUL4A or CUL4B), DDB1, DTL/CDT2 and RBX1 (PubMed:16861906, PubMed:17085480, PubMed:16949367, PubMed:17041588, PubMed:18794347, PubMed:18794348, PubMed:23478441). Interacts with CDKN1A (PubMed:23213251). Interacts with DDB1 (PubMed:16949367, PubMed:23478445). Interacts with FBXO11; SCF(FBXWO11) controls DTL stability but DCX(DTL) does not control FBXO11 stability (PubMed:23478445, PubMed:23478441). Interacts with CRY1 (PubMed:26431207).
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