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DUOX2
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Ductal cells, Distal enterocytes, Exocrine glandular cells, Urothelial cells, Gastric mucus-secreting cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (HaCaT)
Interaction
Heterodimer with DUOXA2; disulfide-linked. Interacts with TXNDC11, TPO and CYBA.
Molecular function
Oxidoreductase, Peroxidase
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