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DUSP16
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Granulosa cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enhanced (NTERA-2, RT4)
Interaction
Interacts with ARRB2.
Molecular function
Hydrolase, Protein phosphatase
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