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EEF2K

Anti-EEF2K Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Bipolar cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HaCaT, HL-60, HMC-1, NB-4)

Interaction

Monomer or homodimer (Probable). Interacts with Calmodulin/CALM1; this interaction is strictly required for phosphorylation activity (PubMed:11015200).

Molecular function

Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase

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