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EIF4E2
Loading...Anti-EIF4E2 Products
- Mouse Anti-NHP EIF4E2 Recombinant Antibody (clone OTI1C1) (VS-1024-XY183)
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- Species Reactivity: Dog, Human, Non-human primate
- Type: Mouse IgG1
- Application: WB, IHC
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- Anti-EIF4E2 Immunohistochemistry Kit (VS-0525-XY2230)
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- Species Reactivity: Human
- Target: EIF4E2
- Application: IHC
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- Anti-Mouse EIF4E2 Immunohistochemistry Kit (VS-0525-XY2231)
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- Species Reactivity: Human, Mouse
- Target: EIF4E2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Enables ubiquitin protein ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (PubMed:15153109, PubMed:17368478). Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3) (By similarity). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:22751931). Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct (PubMed:22751931). Interacts with EIF4ENIF1/4E-T (via YXXXXLphi motif); increasing affinity for the 7-methylguanosine-containing mRNA cap (PubMed:23991149, PubMed:28487484).
Molecular function
Initiation factor, RNA-binding
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Related Signaling Pathways
MAPK Signaling Pathway