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EPM2A
Anti-EPM2A Recombinant Antibody Products
- Human Anti-EPM2A Recombinant Antibody (clone hN84/37.1) (VS-0422-LC124)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ICC, KO/KD-WB, WB, IHC
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- Mouse Anti-EPM2A Recombinant Antibody (clone mN84/37.1) (VS-0422-LC123)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ICC, KO/KD-WB, WB, IHC
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For Research Use Only. Not For Clinical Use.
EPM2A (EPM2A Glucan Phosphatase, Laforin) is a Protein Coding gene. This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Diseases associated with EPM2A include Myoclonic Epilepsy Of Lafora and Dentatorubral-Pallidoluysian Atrophy.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Early spermatids, Excitatory neurons)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enhanced (Daudi)
Interaction
Homodimer (PubMed:16971387, PubMed:18617530, PubMed:23922729, PubMed:25538239, PubMed:25544560). Interacts with itself (PubMed:14532330). Interacts with PPP1R3B, PPP1R3C, PPP1R3D, HIRIP5, and EPM2AIP1 (PubMed:12782127, PubMed:12915448, PubMed:14532330, PubMed:16901901, PubMed:18070875). Binds glycogen and Lafora bodies (PubMed:11739371, PubMed:14532330, PubMed:14706656, PubMed:15102711, PubMed:18617530, PubMed:22036712). Interacts with NHLRC1/malin (via the NHL repeats) (PubMed:15930137, PubMed:22036712, PubMed:23922729). Forms a complex with NHLRC1/malin and HSP70 (PubMed:19036738). Interacts with PPP1R3D; in the presence of NHLC1/malin the interaction leads to ubiquitination and autophagic degradation of PPP1R3D. Interacts (via the phosphatase domain) with MAPT/Tau; the interaction dephosphorylates MAPT (PubMed:19542233). Isoform 1 and isoform 2 interact to form a heterodimeric complex that lacks phosphatase activity (in vitro) (PubMed:18617530). Active phosphatase isoform 7 and isoform 1 interact with each other, but give rise to lower phosphatase activity than isoform 1 or isoform 7 by themselves (in vitro) (PubMed:22036712). Active phosphatase isoform 7 and inactive isoform 2 interact with each other, but give rise to lower phosphatase activity than isoform 7 by itself (in vitro) (PubMed:22036712). Interacts with PRDM8 (PubMed:22961547).
Molecular function
Hydrolase, Protein phosphatase
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