Loading...
EPRS
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Extravillous trophoblasts, Hofbauer cells, Cytotrophoblasts, Syncytiotrophoblasts, Adipocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:24100331, PubMed:23263184). Part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex (MSC), that is composed of the tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:24312579, PubMed:19131329, PubMed:19289464). Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928). Interacts with TARS3 (PubMed:24312579). Interacts with DUS2L (PubMed:15994936). Component of the GAIT complex which is composed of EPRS1, RPL13A and GAPDH. For human, the complex assembly seems to be a two-step process in which EPRS1 first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding (PubMed:15479637). Interacts (phosphorylated at Ser-999) with SLC27A1; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239).
Molecular function
Aminoacyl-tRNA synthetase, Ligase, Multifunctional enzyme, RNA-binding
More Types Infomation
- Mouse Anti-EPRS Recombinant Antibody; Fab Fragment (HPAB-0697LY-F(E)) (HPAB-0697LY-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
- Mouse Anti-EPRS Recombinant Antibody; scFv Fragment (HPAB-0697LY-S(P)) (HPAB-0697LY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
- Mouse Anti-EPRS Recombinant Antibody (HPAB-0697LY) (HPAB-0697LY)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.