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EXOC4
Anti-EXOC4 Recombinant Antibody Products
- PDZ domain scaffold protein anti-Human Sec8 (SPD-L172)
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- Scaffold Name: PDZ domain
- Target: Sec8
- Species Reactivity: Human
- Derivation: Yeast Two-hybrid
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Microglial cells, Excitatory neurons, Inhibitory neurons, Astrocytes, Rod photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce (PubMed:18329369). Interacts with MYRIP (By similarity). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).
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