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FGR
Loading...Anti-FGR Products
- Mouse Anti-FGR Recombinant Antibody (clone 6G2) (VS3-XY712)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP, WB
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IHC-p, IF, ELISA
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- Anti-FGR Immunohistochemistry Kit (VS-0525-XY2550)
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- Species Reactivity: Human
- Target: FGR
- Application: IHC
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- Anti-Mouse FGR Immunohistochemistry Kit (VS-0525-XY2551)
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- Species Reactivity: Human, Mouse, Rat
- Target: FGR
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, Kupffer cells, monocytes, Macrophages, Langerhans cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Group enriched (Daudi, U-266/70)
Interaction
Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1. Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation. Interacts with PIK3R1 and FASLG (By similarity). Interacts with CLNK (By similarity).
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
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