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FICD
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For Research Use Only. Not For Clinical Use.
Background
Protein AMPylation, the transfer of AMP from ATP to protein targets, has been recognized as a new mechanism of host-cell disruption by some bacterial effectors that typically contain a FIC-domain. Eukaryotic genomes also encode one FIC-domain protein, HYPE, which has remained poorly characterized.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids, Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:25435325). Interacts with HD (PubMed:9700202).
Molecular function
Hydrolase, Nucleotidyltransferase, Transferase
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