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FK-506
Loading...Anti-FK-506 Products
- Recombinant Mouse Anti-FK-506 Antibody (clone C247M) (MOB-0212MZ)
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- Species Reactivity: N/A
- Type: Mouse antibody
- Application: ELISA
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- Mouse Anti-FK-506 Recombinant Antibody (clone CBS385) (MRO-A1917-YJ)
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- Type: Mouse IgM
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.
Background
FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/ml and depends on the patient's liver function, the nature of organ transplantation, and the time after transplantation.