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FOXE1
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For Research Use Only. Not For Clinical Use.
Background
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal squamous epithelial cells, Basal respiratory cells, Squamous epithelial cells, Urothelial cells, Spermatogonia, Cardiomyocytes, Club cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A-431, BJ hTERT+, HaCaT, HeLa, RPTEC TERT1, SiHa)
Molecular function
DNA-binding
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