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For Research Use Only. Not For Clinical Use.
G-protein coupled receptors
Membrane
Cell type enhanced (Macrophages, Late spermatids, monocytes, Kupffer cells, Hofbauer cells, Early spermatids)
Immune cell enriched (neutrophil)
Cell line enriched (U-937)
Interacts with Amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized. (Microbial infection) Interacts with Staphylococcus aureus protein SSL13; this interaction leads to the activation of neutrophils.
G-protein coupled receptor, Receptor, Transducer