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FRAT1
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Kupffer cells, Bipolar cells)
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Low cell line specificity
Interaction
Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.
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