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FTH1
Loading...Anti-FTH1 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IHC
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- Rabbit Anti-FTH1 Recombinant Antibody (clone CBACN-224) (MRO-0573-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF
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- Rabbit Anti-FTH1 Recombinant Antibody (clone JM22-36) (MRO-0574-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IF
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- Mouse Anti-FTH1 Recombinant Antibody (clone CBF098) (MOB-201YJL)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Scaffold Name: TEM-1 β-lactamase
- Target: Ferritin
- Species Reactivity: Human
- Derivation: Phage display
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Anti-FTH1 Immunohistochemistry Kit (VS-0525-XY2660)
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- Species Reactivity: Human
- Target: FTH1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, monocytes, Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, HHSteC)
Interaction
Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. In the human liver, the heavy chain is predominant. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Molecular function
Oxidoreductase
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