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    For Research Use Only. Not For Clinical Use.


    Is your epigenetic research being impeded by prolonged R&D timelines and variable antibody efficacy? Creative Biolabs' anti-FTO recombinant antibodies leverage advanced phage display technology and mammalian expression systems to deliver exceptional specificity, accelerating in vivo validation of FTO-mediated RNA demethylation pathways and streamlining therapeutic development for metabolic disorders and cancers.

    FTO: A Master Regulator of RNA Methylation

    Creative Biolabs' recombinant antibodies target FTO (alpha-ketoglutarate-dependent dioxygenase FTO), a key RNA demethylase implicated in obesity, metabolic syndrome, and cancer progression. Engineered for high affinity and low cross-reactivity, these antibodies enable precise detection and functional modulation of FTO across diverse experimental models.

    Alternative Names

    Fat mass and obesity-associated protein; ALKBH9; EC 1.14.11.33; obesity-associated protein.

    Background

    This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
    FTO
    Protein class

    Disease related genes, Enzymes, Human disease related genes, Potential drug targets

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Respiratory ciliated cells, Astrocytes)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    Interaction

    Monomer (By similarity). May also exist as homodimer (By similarity).

    Molecular function

    Dioxygenase, Oxidoreductase, Transferase

    More Types Infomation

    Anti-FTO rAb Products

    Anti-FTO antibodies from Creative Biolabs merge stringent validation procedures with exceptional versatility. Available in multiple host species (humanized, mouse, rabbit) and formats (IgG, scFv), they support applications ranging from ChIP-seq and RNA-protein interaction studies to in vivo therapeutic efficacy testing.

    Cat. No. Product Name Target Species Host Species Applications
    MOB-373 Recombinant Anti-human FTO Antibody Human Mouse ELISA, WB, Flow Cytometry
    MHH-373 Recombinant Human Anti-human FTO Antibody Human Human ELISA, IF
    VS3-FY568 Recombinant Rabbit Anti-FTO Antibody (clone R04-1F7) Human Rabbit WB, IHC-P
    MHH-373-S(P) Recombinant Human Anti-human FTO Antibody scFv Fragment Human Human WB, Neutralization.

    Table.1 Featured anti-FTO recombinant antibody products at Creative Biolabs.

    Creative Quality Control

    Every anti-FTO antibody undergoes orthogonal validation, such as ELISA, to ensure epitope specificity and batch-to-batch consistency. Our ISO-certified pipelines guarantee >95% purity, empowering reproducible results in high-stakes research.

    WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-FTO antibody.
    (Cat# VS3-FY568, Creative Biolabs).

    IF staining. (Creative Biolabs Original)Fig.2 IF-staining result of anti-AHSP antibody.
    (Cat# MHH-373, Creative Biolabs).

    IF analysis. (Creative Biolabs Original)Fig.3 IF analysis of anti-FTO antibody.
    (Cat# MHH-373, Creative Biolabs).

    IHC analysis. (Creative Biolabs Original)Fig.4 Colon IHC staining result of anti-FTO antibody.
    (Cat# VS3-FY568, Creative Biolabs).

    Customer Reviews

    Excellent
    Mar**k T.
    Recombinant Human Anti-human FTO Antibody scFv Fragment
    The humanized anti-FTO scFv (Cat# MHH-373-S(P)) showed exceptional tumor penetration in our glioblastoma xenografts, outperforming conventional IgG formats.
    11/Aug/2024
    Excellent
    Ni**a W
    Recombinant Anti-human FTO Antibody
    Creative Biolabs' anti-FTO antibody (Cat# MOB-373) enabled precise m6A quantification in our obesity models, eliminating background noise in RNA pulldown assays.
    13/May/2023
    Excellent
    An**a S.
    Recombinant Anti-human FTO Antibody
    Consistent FTO detection across FFPE tissues and cell lysates using Cat# MOB-373 streamlined our translational cancer studies.
    10/Mar/2024

    rAb Production

    Our serum-free mammalian platform integrates codon-optimized gene synthesis with perfusion bioreactors, achieving gram-scale yields of bioactive FTO antibodies. From subcloning to endotoxin-free purification, we ensure compliance with preclinical standards.

    Featured Anti-FTO Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
    Fig.5 Synthesis of milligram-scale recombinant antibodies against FTO.

    Gram-scale. (Creative Biolabs Original)Fig.6 Generation of gram-scale quantities of recombinant antibodies targeting FTO.

    rAb Modalities

    Tailor your research with FTO-specific fragments (Fab), bispecifics, or Fc-engineered variants. Our modular designs accommodate complex applications, including cell targeting and intracellular epitope engagement.

    FTO antibody production and modalities. (Creative Biolabs Original)Fig.7 Approaches and techniques for synthesizing complete recombinant antibodies against FTO.

    Creative Biolabs facilitates pioneering epigenetics research through meticulously validated anti-FTO tools. Contact our team to explore custom antibody solutions or request a product dossier.

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