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GABBR1
Anti-GABBR1 Recombinant Antibody Products
- Mouse Anti-GABBR1 Recombinant Antibody (VS-0522-LC98) (VS-0522-LC98)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: IP, WB, IF
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- Rat Anti-GABBR1 Recombinant Antibody (VS-0522-LC99) (VS-0522-LC99)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: IP, WB, IF
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- Human Anti-GABBR1 Recombinant Antibody (VS-0522-LC100) (VS-0522-LC100)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: IP, WB, IF
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- Rabbit Anti-GABBR1 Recombinant Antibody (VS-0522-LC101) (VS-0522-LC101)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: IP, WB, IF
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- Rabbit Anti-GABBR1 Recombinant Antibody (VS3-WK1188) (VS3-WK1188)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined.
Protein class
FDA approved drug targets, G-protein coupled receptors, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AN3-CA, HEL, U-2 OS)
Interaction
Heterodimer of GABBR1 and GABBR2 (PubMed:9872316, PubMed:10773016, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Homodimers may form, but are inactive (PubMed:9872316, PubMed:15617512). Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABBR2 (PubMed:10906333). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity). Interacts with JAKMIP1 (PubMed:14718537).
Molecular function
G-protein coupled receptor, Receptor, Transducer
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