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GABRB1
Loading...Anti-GABRB1 Products
- Rat Anti-GABRB1 Recombinant Antibody (clone rtN96/55.3) (VS-0422-LC83)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB
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- Human Anti-GABRB1 Recombinant Antibody (clone hN96/55.3) (VS-0422-LC84)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB
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- Rat Anti-GABRB1 Recombinant Antibody (VS-0522-LC95) (VS-0522-LC95)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB
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- Human Anti-GABRB1 Recombinant Antibody (VS-0522-LC96) (VS-0522-LC96)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB
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- Rabbit Anti-GABRB1 Recombinant Antibody (VS-0522-LC97) (VS-0522-LC97)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: WB
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- Anti-GABRB1 Immunohistochemistry Kit (VS-0525-XY2709)
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- Species Reactivity: Human
- Target: GABRB1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
GABRB1 (Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1) is a Protein Coding gene. This gene encodes GABA A receptor, beta 1 subunit. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. Diseases associated with GABRB1 include Developmental And Epileptic Encephalopathy 45 and Schizoaffective Disorder.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Astrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (REH, U-87 MG)
Interaction
Binds UBQLN1 (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity).
Molecular function
Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
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