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GABRB2
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:8264558, PubMed:29950725). Interacts with UBQLN1 (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). May interact with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity).
Molecular function
Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.