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GATA6
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For Research Use Only. Not For Clinical Use.
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Cardiomyocytes, Granulosa cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (BEWO, CACO-2, hTERT-RPE1, OE19)
Interaction
Interacts with LMCD1.
Molecular function
Activator, DNA-binding
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