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GCK
Anti-GCK Recombinant Antibody Products
- Mouse Anti-GCK Recombinant Antibody (clone 4G6) (VS3-XY768)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-GCK Recombinant Antibody (clone 22H3) (MOB-3021z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Mouse Anti-GCK Recombinant Antibody (clone CBL318HM) (VS7-HM1000)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Anti-GCK Immunohistochemistry Kit (VS-0325-XY907)
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- Species Reactivity: Human, Mouse, Rat
- Target: GCK
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Fibroblasts, Horizontal cells, Bipolar cells, Cardiomyocytes, Smooth muscle cells)
Immune cell specificity
Immune cell enhanced (memory B-cell, naive CD4 T-cell)
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Monomer (PubMed:15016359, PubMed:19362831, PubMed:23957911). Interacts with MIDN; the interaction occurs preferentially at low glucose levels and results in inhibition of hexokinase activity (PubMed:24187134). Interacts with GCKR; leading to sequestration in the nucleus (PubMed:10456334).
Molecular function
Allosteric enzyme, Kinase, Transferase
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