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GDF1
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. Mutations in this gene are associated with several congenital cardiovascular malformations.
Protein class
Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Not detected
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (EFO-21, SH-SY5Y)
Interaction
Homodimer; disulfide-linked.
Molecular function
Cytokine, Growth factor
More Types Infomation