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GKN2
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For Research Use Only. Not For Clinical Use.
Background
The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa.
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Gastric mucus-secreting cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A549, HaCaT, HMC-1, MOLT-4, NTERA-2, PC-3, U-2 OS, U-266/70)
Interaction
Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.
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